Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming

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• 作者：Inê ; s Milagre¹ ; ⁷ ; ^{ines.milagre@babraham.ac.uk} ; Thomas M. Stubbs¹ ; Michelle R. King¹ ; Julia Spindel¹ ; Fá ; tima Santos¹ ; Felix Krueger² ; Martin Bachman³ ; ⁴ ; Anne Segonds-Pichon² ; Shankar Balasubramanian³ ; ⁴ ; Simon R. Andrews² ; Wendy Dean¹ ; Wolf Reik¹ ; ⁵ ; ⁶ ; ⁸ ; ^{wolf.reik@babraham.ac.uk}
• 关键词：reprogramming ; iPSCs ; DNA methylation ; gender differences ; AID ; UHRF1
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1079-1089
• 全文大小：3265 K
• 卷排序：18

文摘

iPSC reprogramming induces transient genome-wide DNA demethylation Global demethylation is more pronounced in female iPSCs AID is a critical regulator of UHRF1 protein and genome-wide DNA demethylation Targeted DNA demethylation occurs at key regulatory regions and is uncoupled from global demethylation