Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

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Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

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作者：Ivan Vujkovic-Cvijin¹ ; Louise A. Swainson¹ ; Simon N. Chu¹ ; ² ; Alexandra M. Ortiz³ ; Clark A. Santee⁴ ; Annalise Petriello¹ ; Richard M. Dunham¹ ; ¹⁰ ; Douglas W. Fadrosh⁴ ; Din L. Lin⁴ ; Ali A. Faruqi⁴ ; Yong Huang⁵ ; Cristian Apetrei⁶ ; Ivona Pandrea⁶ ; Frederick M. Hecht⁷ ; Christopher D. Pilcher⁷ ; Nichole R. Klatt⁸ ; Jason M. Brenchley³ ; Susan V. Lynch⁴ ; ⁹ ; ^{susan.lynch@ucsf.edu" class="auth_mail" title="E-mail the corresponding author} ; Joseph M. McCune¹ ; ⁹ ; ^{mike.mccune@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2015
出版时间：24 November 2015
年：2015
卷：13
期：8
页码：1589-1597
全文大小：1225 K

文摘

•: IDO1 activity correlates with loss of barrier-promoting Th17 cells in SIV infection
•: Abundance of gut-resident m>Lactobacillusm> correlates with IDO1 activity and Th17 cells
•: Probiotics containing m>Lactobacillusm> reduce IDO1 activity in SIV-infected macaques

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