Effect of glandular metastases on overall survival of patients with metastatic clear cell renal cell carcinoma in the antiangiogenic therapy era

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Effect of glandular metastases on overall survival of patients with metastatic clear cell renal cell carcinoma in the antiangiogenic therapy era

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作者：Gwenaelle Gravis ; M.D.^a ; ^{gravisg@ipc.unicancer.fr" class="auth_mail" title="E-mail the corresponding author} ; ^{brice.chanez@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Brice Chanez ; M.D.^a ; Lisa Derosa ; M.D.^b ; Benoit Beuselinck ; M.D.^c ; Philippe Barthelemy ; M.D.^d ; Brigitte Laguerre ; M.D.^e ; Pierre-Emmanuel Brachet ; M.D.^f ; Florence Joly ; M.D.^f ; Bernard Escudier ; M.D.^b ; David J. Harrison ; M.D.^g ; Alexander Laird ; M.B.Ch.B. ; M.R.C.S.^h ; Naveen Vasudev ; M.B.Ch.B. ; Ph.D. ; M.R.C.P. ; B.M.Sc.ⁱ ; Christy Ralph ; A.P.ⁱ ; James Larkin ; M.A. ; F.R.C.P. ; Ph.D.^j ; Hazel Lote ; M.A. ; M.B.B.S. ; M.R.C.P.^j ; Naji Salem ; M.D.^k ; Jochen Walz ; M.D.^l ; Jeanne Thomassin ; M.D.^m ; Patrick Sfumato ; Ph.D.ⁿ ; Grant D. Stewart ; B.Sc. (Hons) ; F.R.C.S.Ed. (Urol) ; M.B.Ch.B. ; Ph.D.^h ; Jean Marie Boher ; Ph.D.ⁿ ; On behalf of the Renal Cross Channel Group
关键词：Kidney cancer ; Clear cell renal carcinoma ; Prognosis factors ; Glandular metastases ; Survival outcome ; Targeted therapies ; Antiangiogenic therapy
刊名：Urologic Oncology: Seminars and Original Investigations
出版年：2016
出版时间：April 2016
年：2016
卷：34
期：4
页码：167.e17-167.e23
全文大小：415 K

文摘

•: This retrospective multicenter study included metastatic renal cell carcinoma (mRCC).
•: mRCC was treated with antiangiogenics and glandular metastasis (GM) was recorded.
•: Metastases to the pancreas, adrenal gland, breast, thyroid, or parotid defined GM.
•: Patients with GM as first metastatic presentation had longer overall survival.
•: The GM localization was an independent prognostic factor for survival.

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