AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

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AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

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作者：Kelly M. Cautivo¹ ; ² ; ³ ; Carlos O. Lizama⁴ ; Pablo J. Tapia¹ ; Anil K. Agarwal⁵ ; Abhimanyu Garg⁵ ; Jay D. Horton² ; ³ ; ^{jay.horton@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author} ; Ví ; ctor A. Corté ; s¹ ; ^{vcortes@med.puc.cl" class="auth_mail" title="E-mail the corresponding author}
关键词：AGPAT2 ; Adipose tissue ; Adipogenesis ; Phospholipid ; Lipodystrophy
刊名：Molecular Metabolism
出版年：2016
出版时间：July 2016
年：2016
卷：5
期：7
页码：491-505
全文大小：10379 K

文摘

•: Post weaning Agpat2^−/− mice are lipodystrophic.
•: However, they are born with normal mass of white and brown adipose tissue.
•: Adipose tissue in Agpat2^−/− mice undergoes postnatal inflammatory cell death.
•: Differentiated Agpat2^−/− MEFs recapitulate abnormalities of Agpat2^−/− adipocytes.
•: Abnormal phospholipid composition might underlies lipodystrophy in Agpat2^−/− mice.

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