The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression

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• 作者：Jun Hyun Kim¹ ; Malgorzata Grosbart² ; ³ ; Roopesh Anand⁴ ; Claire Wyman² ; ³ ; Petr Cejka⁴ ; John H.J. Petrini¹ ; ⁵ ; ^{petrinij@mskcc.org}
• 关键词：Nbs1mid mutants ; Mre11-Nbs1 interface ; ATM activation ; Mre11 complex assembly
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：496-507
• 全文大小：3361 K
• 卷排序：18

文摘

TALEN editing used to generate Nbs1mid mutant mice altered the Mre11 interaction The Mre11-Nbs1 interaction is essential for embryonic viability and DDR The Nbs1 minimal fragment (108 amino acid) is sufficient to sustain viability Nbs1 is required for proper assembly and localization of Mre11 and Rad50