The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues

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The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues

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作者：Naomi L. Cook^a ; Cassidy H. Moeke^a ; ^b ; Luca I. Fantoni^a ; David I. Pattison^a ; ^b ; Michael J. Davies^a ; ^b ; ^c ; ^{davies@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author}
关键词：BSA ; bovine serum albumin ; CK ; creatine kinase ; DMSO ; dimethylsulfoxide ; DTNB ; 5 ; 5&prime ; -dithio-(2-nitrobenzoic acid) ; DTT ; dithiothreitol ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HBSS ; Hank's buffered salt solution without calcium and magnesium ; HMDM ; human monocyte-derived macrophages ; HRP ; horseradish peroxidase ; IAF ; iodoacetamidofluorescein ; LDH ; lactate dehydrogenase ; LPO ; lactoperoxidase ; MAPK ; mitogen-activated protein kinase ; MPO ; myeloperoxidase ; PBS ; phosphate-buffered salin
刊名：Free Radical Biology and Medicine
出版年：2016
出版时间：January 2016
年：2016
卷：90
期：Complete
页码：195-205
全文大小：1783 K

文摘

•: Protein tyrosine phosphatases (PTPs) are key regulators of protein phosphorylation.
•: Myeloperoxidase is a major generator of inflammatory oxidants including HOSCN.
•: HOSCN is shown to inactivate PTPs by oxidation of redox-sensitive Cys residues.
•: Oxidation involves sulfenic acid or sulfenyl-thiocyanate (RS–SCN) intermediates.

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