Superoxide dismutase 1 and glutathione peroxidase 1 are involved in the protective effect of sulodexide on vascular endothelial cells exposed to oxygen-glucose deprivation

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Superoxide dismutase 1 and glutathione peroxidase 1 are involved in the protective effect of sulodexide on vascular endothelial cells exposed to oxygen-glucose deprivation

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作者：Bożena Gabryel^a ; ^{bgabryel@interia.pl" class="auth_mail" title="E-mail the corresponding author} ; Karolina Jarząbek^a ; Grzegorz Machnik^b ; Jakub Adamczyk^c ; Dariusz Belowski^b ; Ewa Obuchowicz^a ; Tomasz Urbanek^d
关键词：CAT ; catalase ; DCF-DA ; 2&prime ; 7&prime ; -dichlorofluorescein diacetate ; DS ; dermatan sulfate ; eNOS ; endothelial nitric oxide synthase ; FBS ; fetal bovine serum ; FMH ; fast-moving heparin fraction ; GAGs ; glycosaminoglycans ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; GPx ; glutathione peroxidase ; GSH ; glutathione ; HBSS ; Hank's buffered salt solution ; HRP ; horseradish peroxidase ; HUVEC ; human umbilical vein endothelial cells ; JC-1 ; 5 ; 5&prime ; 6 ; 6&prime ; -tetrachloro-1 ; 1&prime ; 3 ; 3&prime ; -tetraeth
刊名：Microvascular Research
出版年：2016
出版时间：January 2016
年：2016
卷：103
期：Complete
页码：26-35
全文大小：922 K

文摘

•: SDX protects HUVEC from OGD-induced apoptosis.
•: SDX attenuates ROS production and lipid peroxidation in HUVEC exposed to OGD.
•: SDX increases SOD1 and GPx1 mRNA/protein expression in ischemic HUVEC.
•: SDX increases SOD and GPx activity in ischemic HUVEC.
•: SDX prevents of eNOS uncoupling in HUVEC exposed to OGD.