MiR-23b controls TGF-β1 induced airway smooth muscle cell proliferation via TGFβR2/p-Smad3 signals

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MiR-23b controls TGF-β1 induced airway smooth muscle cell proliferation via TGFβR2/p-Smad3 signals

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作者：Ming Chen^a ; Linjie Huang^a ; ¹ ; Wei Zhang^b ; Jianting Shi^a ; Xiaoling Lin^a ; Zhiqiang Lv^a ; Wei Zhang^a ; Ruiyun Liang^a ; Shanping Jiang^a ; ^{shanpingjiang@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：ASMCs ; airway smooth muscle cells ; BSA ; bovine serum albumin ; DMEM ; Dulbecco&rsquo ; s modiﬁed Eagle&rsquo ; s medium ; Smad ; drosophila mothers against decapentaplegic protein ; FBS ; fetal bovine serum ; HBSS ; Hanks&rsquo ; balanced salt solution ; NC ; negative control ; PBS ; phosphate-buffered saline ; PVDF ; polyvinylidene difluoride ; TGF-β1 ; transforming growth factor-β1 ; TGFβR2 ; transforming growth factor-β1 receptor II
刊名：Molecular Immunology
出版年：2016
出版时间：February 2016
年：2016
卷：70
期：Complete
页码：84-93
全文大小：3665 K

文摘

•: Overexpression of miR-23b significantly inhibited TGF-β1-induced
•: ASMCs proliferation and promoted apoptosis.
•: MiR-23b negatively regulates the expression of TGFβR2 and p-Smad3 in ASMCs.
•: MiR-23b may function as an inhibitor of asthma airway remodeling by suppressing ASMCs proliferation through inactivation of TGFβR2/p-Smad3 pathway.

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