Mitochondrial DNA haplogroups modify the risk of osteoarthritis by altering mitochondrial function and intracellular mitochondrial signals

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Mitochondrial DNA haplogroups modify the risk of osteoarthritis by altering mitochondrial function and intracellular mitochondrial signals

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作者：Hezhi Fang^a ; ¹ ; ^{hezhifang990909@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Fengjiao Zhang^a ; ¹ ; Fengjie Li^a ; ¹ ; Hao Shi^a ; Lin Ma^a ; Miaomiao Du^a ; Yanting You^a ; ¹ ; Ruyi Qiu^a ; Hezhongrong Nie^a ; Lijun Shen^a ; Yidong Bai^a ; ^b ; ^{baiy@uthscsa.edu" class="auth_mail" title="E-mail the corresponding author} ; Jianxin Lyu^a ; ^{jxlu313@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：ACSS2 ; acyl-CoA synthetase short-chain family member 2 ; ALDH1A3 ; aldehyde dehydrogenase family 1 member A3 ; AP-1 ; transcription factor AP-1 ; BNGE ; blue native PAGE ; BPGM ; 2 ; 3-bisphosphoglycerate mutase ; Cybrid ; cytoplasmic hybrid ; 2-DG ; 2-deoxyglucose ; DDM ; n-dodecyl β-d-maltoside ; DEG ; differentially expressed gene ; ECM ; extracellular matrix ; GMCSF2 ; granulocyte-macrophage colony-stimulating factor ; G6PC3 ; glucose-6-phosphatase 3 ; HBSS ; Hank's buffered salt solution ; HIF ; hypoxia-inducible fact
刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年：2016
出版时间：April 2016
年：2016
卷：1862
期：4
页码：829-836
全文大小：813 K

文摘

•: Haplogroup G presents a metabolic shift from glycolysis to oxidative phosphorylation in the comparison of haplogroup B4.
•: Haplogroup B4 facilitates cell growth under hypoxia.
•: Levels of osteoarthritis related genes expression are different between G and B4 cybrids.

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