Transplantation of bone marrow mononuclear cells prolongs survival, delays disease onset and progression and mitigates neuronal loss in pre-symptomatic, but not symptomatic ALS mice
We investigate the effect of bone marrow mononuclear cells (BMMC) in ALS mice.
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Pre-symptomatic BMMC transplantation improves the animal’s clinical condition.
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Only non-mSOD1 BMMC are beneficial in late symptomatic animals.
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Early administration of BMMC promotes better outcomes.
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