A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22

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• 作者：Tobias Engel ; ^{tengel@rcsi.ie} ; Gary P. Brennan ; Amaya Sanz-Rodriguez ; Mariana Alves ; Edward Beamer ; Orla Watters ; David C. Henshall ; Eva M. Jimenez-Mateos
• 关键词：CA1 and 3 ; Cornu amonis 1 and 3 ; ChIP ; chromatin immunoprecipitation ; DG ; Dentate gyrus ; IATF ; Injury-activated transcription factor family ; IL-1β ; Interleukin-1β ; miRNA ; microRNA ; NMDAR ; N-methyl-D-aspartate receptor ; p2rx7 ; P2X7 receptor gene name ; P2X7R ; purinergic P2X7 receptor ; Sp1 ; Specificity protein 1
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：255-266
• 全文大小：1452 K
• 卷排序：1864

文摘

Specificity protein 1 drives P2rx7 and microRNA-22 transcription in vitro. Specificity protein 1 induces P2rx7 and microRNA-22 transcription in the brain after prolonged seizures. Binding of specificity protein 1 to the promoter region of microRNA-22 is dependent on neuronal activity. Specificity protein 1-induced transcription of microRNA-22 is dependent on intracellular calcium levels.