Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

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Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

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作者：Ivan Qué ; tier¹ ; Jacqueline J.T. Marshall² ; Bradley Spencer-Dene³ ; Sylvie Lachmann² ; Adele Casamassima² ; Claudio Franco⁴ ; Sarah Escuin⁵ ; Joseph T. Worrall⁶ ; Priththivika Baskaran¹ ; Vinothini Rajeeve⁶ ; Michael Howell³ ; Andrew J. Copp⁵ ; Gordon Stamp³ ; Ian Rosewell⁷ ; Pedro Cutillas⁶ ; Holger Gerhardt⁸ ; Peter J. Parker² ; ⁹ ; ^{peter.parker@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Angus J.M. Cameron¹ ; ^{a.cameron@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：PKC ; protein kinase C ; PKN ; Protein kinase N ; MEF ; mouse embryonic fibroblasts ; ES cells ; Embryonic stem cells ; 4-OHT ; 4-hydroxytamoxifen ; NCCs ; neural crest cells
刊名：Cell Reports
出版年：2016
出版时间：26 January 2016
年：2016
卷：14
期：3
页码：440-448
全文大小：3298 K

文摘

•: PKN2, but not PKN1 or PKN3, is essential during mouse embryogenesis
•: PKN2 knockout causes severe cardiovascular and morphogenetic abnormalities
•: PKN2 is required for mesenchymal growth and neural crest migration in vivo

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