Fungicidal activity of truncated analogues of dihydrosphingosine

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• 作者：Karin Thevissen ; Ulrik Hillaert ; Els M.K. Meert ; Kuen K. Chow ; Bruno P.A. Cammue ; Serge Van Calenbergh ; Isabelle E.J.A. Franç ; ois
• 关键词：Sphingoid base ; Dihydrosphingosine ; Fungicidal ; Candida albicans ; Candida glabrata ; Reactive oxygen species
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2008
• 出版时间：1 July 2008
• 年：2008
• 卷：18
• 期：13
• 页码：3728-3730
• 全文大小：186 K

文摘

The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.