Major triterpenoids in Chinese hawthorn “Crataegus pinnatifida” and their effects on cell proliferation and apoptosis induction in MDA-MB-231 cancer cells

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• 作者：Lingrong Wen^a ; ^b ; Ruixue Guo^a ; ^b ; Lijun You^a ; ^b ; ^{feyoulijun@scut.edu.cn} ; Arshad Mehmood Abbasi^a ; ^d ; Tong Li^c ; Xiong Fu^a ; ^b ; Rui Hai Liu^c
• 关键词：Crataegus pinnatifida ; MDA-MB-231 ; Ursolic acid ; Apoptosis ; Cell cycle ; Semi-preparative HPLC
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：149-160
• 全文大小：1824 K
• 卷排序：100

文摘

Shanlihong had potent antiproliferative effect against human cancer cells lines. Triterpenoids-enriched fraction (S9) with potent anticancer activity was prepared by semi-preparative HPLC. S9 fraction and ursolic acid induced MDA-MB-231 cells apoptosis through mitochondrial death pathway. S9 fraction and ursolic acid inhibit cell proliferation via PCNA, Cyclin D1 and CDK4 down-regulation and p21 up-regulation. S9 fraction and ursolic acid may responsible for the potent anticancer activity of Chinese hawthorn.