Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation

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Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation

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作者：Tong Liu^a ; Changgong Wu^a ; Mohit Raja Jain^a ; Narayani Nagarajan^b ; Lin Yan^a ; Huacheng Dai^a ; Chuanlong Cui^a ; Ahmet Baykal^a ; Stacey Pan^a ; Tetsuro Ago^b ; Junichi Sadoshima^b ; Hong Li^a ; ^{liho2@rutgers.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：C. I. ; confidence interval ; FDR ; false discovery rate ; GAPDH ; glyceraldehyde-3-phophate dehydrogenase ; ICAT ; isotope-coded affinity tags ; iTRAQ ; isobaric tags for relative and absolute quantitation ; MMTS ; methyl methanethiosulfonate ; PTMs ; post-translational modifications ; ROS ; reactive oxygen species ; SMYD ; SET and MYND domain-containing protein ; SCX ; strong cation exchange ; TCEP ; Tris(2-carboxyethyl)-phosphine ; TEAB ; Triethylammonium bicarbonate buffer ; Tg-Trx1 ; transgenic mice with a cardiac-
刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
出版年：2015
出版时间：December 2015
年：2015
卷：1854
期：12
页码：1816-1822
全文大小：669 K

文摘

•: Trx1 is an antioxidant protein that can protect against cardiac stress.
•: Proteomics approach enabled the discovery of cardiac Trx1 upregulation of SMYD1, a lysine methyltransferase.
•: Trx1 may exert its functions by modulating epigenetic lysine methylation via SMYD1.

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