Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

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• 作者：Maxwell A. Ruby¹ ; Julie Massart¹ ; Devon M. Hunerdosse² ; Milena Schö ; nke¹ ; Jorge C. Correia³ ; Sharon M. Louie² ; Jorge L. Ruas³ ; Erik Nä ; slund⁴ ; Daniel K. Nomura² ; Juleen R. Zierath¹ ; ⁵ ; ^{juleen.zierath@ki.se}
• 关键词：obesity ; hepatic steatosis ; carboxylesterase ; lipidomics ; insulin resistance ; activity-based protein profiling ; inflammation ; diacylglycerol ; serine hydrolase
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：636-646
• 全文大小：2316 K
• 卷排序：18

文摘

Obesity decreases hepatic activity of AADAC and CES2 in humans CES2 depletion impairs lipid and glucose metabolism in primary human hepatocytes Human CES2 expression reverses hepatic steatosis and glucose intolerance in mice CES2 controls a hepatic lipid network dysregulated in human and mouse obesity