Successful vaccination against Leishmania chagasi infection in BALB/c mice with freeze-thawed Leishmania antigen and Corynebacterium parvum

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• 作者：Má ; rcia de Carvalho Vilela ; Daniel Clá ; udio de Oliveira Gomes ; Eduardo de Almeida Marques-da-Silva ; Tiago Donatelli Serafim ; Luis Carlos Crocco Afonso ; Simone Aparecida Rezende
• 关键词：Vaccine ; Leishmania chagasi ; Mice ; IFN-γ ; IL-4
• 刊名：Acta Tropica
• 出版年：2007
• 出版时间：November-December 2007
• 年：2007
• 卷：104
• 期：2-3
• 页码：133-139
• 全文大小：380 K

文摘

This study evaluated the potential of a Leishmania antigen vaccine in protecting BALB/c mice against Leishmania chagasi. Mice received two subcutaneous doses of L. amazonensis vaccine with Corynebacterium parvum and subsequent boost was done without adjuvant. One week later, mice were challenged with L. chagasi. We observed that this vaccine caused a significant reduction in parasite load in liver and spleen and induced a high production of IFN-γ and IL-4 by spleen cells from vaccinated mice in response to Leishmania antigen. Together, our data show that this vaccine is capable of inducing a Th1/Th2 response that is important to control parasite replication.