Cytotoxic and genotoxic effects mediated by M2 muscarinic receptor activation in human glioblastoma cells

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Cytotoxic and genotoxic effects mediated by M2 muscarinic receptor activation in human glioblastoma cells

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作者：Maria Di Bari^a ; Vanessa Tombolillo^a ; Claudia Conte^a ; Emila Castigli^b ; Miriam Sciaccaluga^c ; Egidio Iorio^d ; Giulia Carpinelli^d ; Ruggero Ricordy^e ; Mario Fiore^e ; Francesca Degrassi^e ; Ada Maria Tata^a ; ^{adamaria.tata@uniroma1.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Acetylcholine ; M2 receptors ; Apoptosis ; ROS ; DNA damage
刊名：Neurochemistry International
出版年：2015
出版时间：November 2015
年：2015
卷：90
期：Complete
页码：261-270
全文大小：1433 K

文摘

•: The M2 receptors activation counteracts cell proliferation and survival in glioblastoma.
•: M2 receptors appear an interesting therapeutic tool in glioblastoma therapy.
•: More selective M2 receptor ligands may represent a new promising therapeutic perspective.

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