NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice

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• 作者：Arnaldo H. de Souza^a ; ^b ; Laila R.B. Santos^a ; ¹ ; Leticia P. Roma^b ; ² ; Mohammed Bensellam^a ; Angelo R. Carpinelli^b ; Jean-Christophe Jonas^a ; ^{jean-christophe.jonas@uclouvain.be}
• 关键词：NOX2 ; roGFP sensors ; Pancreatic β-cell ; Insulin secretion ; Apoptosis
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：354-362
• 全文大小：1574 K
• 卷排序：439

文摘

NOX2 was confirmed as a negative modulator of glucose-stimulated insulin secretion. 1 day-culture under glucotoxic condition increased β-cell cytosolic thiol oxidation. 3 weeks-culture under glucotoxic condition altered β-cell function and survival. NOX2 did not contribute to in vitro β-cell glucotoxicity.