Carvedilol does not reduce cocaine use in methadone-maintained cocaine users

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• 作者：Mehmet Sofuoglu ; ^{Mehmet.Sofuoglu@yale.edu} ; James Poling ; Theresa Babuscio ; Kishorchandra Gonsai ; Kevin Severino ; Charla Nich ; Kathleen M. Carroll
• 关键词：Cocaine use disorder ; Carvedilol ; Clinical trial ; Adrenergic blocker
• 刊名：Journal of Substance Abuse Treatment
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：63-69
• 全文大小：511 K
• 卷排序：73

文摘

This study tested the efficacy of carvedilol (CAR), an adrenergic blocker, for cocaine use disorder. Cocaine-dependent participants were randomized to placebo (n = 34), 25 mg/day CAR (n = 37) or 50 mg/day CAR (n = 35). Treatment with either 25 or 50 mg CAR did not reduce cocaine use more than placebo in methadone-maintained cocaine users. These results do not support the potential use of CAR for the treatment of CUD in patients maintained on methadone.