Caryophyllene sesquiterpenoids from the endophytic fungus, Pestalotiopsis sp.

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• 作者：Yi Liu ; Ming-Hua Yang ; ^{skeepjack@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bing Wang ; Tian-Xiao Li ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ethyl ethanoate (PubChem CID ; 8857) ; Methylene chloride (PubChem CID ; 6344) ; Methanol (PubChem CID ; 887) ; Methyl cyanide (PubChem CID ; 6342) ; Pyridine (PubChem CID ; 1049)
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：119-124
• 全文大小：852 K

文摘

Eight new caryophyllene sesquiterpenoids named pestaloporinates A-G (1–7) and 14-acetylhumulane (8) have been isolated from the solid cultures of an endophytic fungus Pestalotiopsis sp., which was obtained from the fresh stem bark of Melia azedarach Linn. Their structures as well as absolute configurations were determined by spectroscopic data, ECD experimentation, and single-crystal X-ray diffraction. Among all the isolates, compound 2 displayed potent inhibitory activity with IC₅₀ value of 19.0 μM during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells.