Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents - Part III

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Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents - Part III

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作者：Luisa Ronga^a ; ^b ; Marco Del Favero^a ; ^b ; Anita Cohen^c ; Claire Soum^a ; ^b ; Patrice Le Pape^d ; Solè ; ne Savrimoutou^a ; ^b ; Noë ; l Pinaud^e ; Catherine Mullié ; ^f ; Sylvie Daulouede^g ; Philippe Vincendeau^g ; Natacha Farvacques^f ; Patrice Agnamey^f ; ^h ; Fabrice Pagniez^d ; Sé ; bastien Hutter^c ; Nadine Azas^c ; Pascal Sonnet^f ; Jean Guillon^a ; ^b ; ^{jean.guillon@u-bordeaux.fr" class="auth_mail}
关键词：Pyrrolo[1 ; 2-a]quinoxaline ; Antileishmanial activity ; Antitrypanosomal activity ; Antimalarial activity ; Synthesis ; Suzuki reaction
刊名：European Journal of Medicinal Chemistry
出版年：23 June 2014
年：2014
卷：81
期：Complete
页码：378-393
全文大小：1036 K

文摘

•: Synthesis of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxaline derivatives.
•: Compounds were tested for antiparasitic activity upon Leishmania spp. strains.
•: Compounds were tested in vitro upon Trypanosoma brucei brucei and Plasmodium falciparum strains.
•: New compounds with IC₅₀ in the micromolar range were identified.

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