Role of Nrf2 in the pathogenesis of atherosclerosis

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Role of Nrf2 in the pathogenesis of atherosclerosis

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作者：Junsei Mimura ; ^{jmimura@hirosaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Ken Itoh
关键词：ABCA1 ; ATP-binding cassette ; sub-family A ; member 1 ; ABCG1 ; ATP-binding cassette ; sub-family G ; member 1 ; ApoE ; apolipoprotein E ; ARE ; antioxidant response element ; ArgII ; arginase II ; CDDO-Im ; 2-cyano-3 ; 12 dioxooleana-1 ; 9 dien-28-imidazolide ; CXCL4 ; chemokine (C-X-C motif) ligand 4 ; Fpn1 ; ferroportin 1 ; GSH ; glutathione ; HDL ; high-density lipoprotein ; HFD ; high fat diet ; HO-1 ; heme oxygenase-1 ; HUVEC ; human umbilical vascular endothelial cell ; ICAM-1 ; intercellular adhesion molecule 1 ; iNOS ; in
刊名：Free Radical Biology and Medicine
出版年：2015
出版时间：November 2015
年：2015
卷：88
期：part_PB
页码：221-232
全文大小：1101 K

文摘

•: Nrf2 exhibits both pro- and anti-atherogenic effects during atherosclerosis development.
•: Nrf2 deficiency in mice accelerates or decelerates atherosclerosis depending on the type of atherosclerosis model mouse.
•: Nrf2 pathway might be a promising target for the prevention of atherosclerosis.

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