Deletion of Btg1 alters cerebellar development and impairs motor coordination.
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Deletion of Btg1 induces highly the proliferation of cerebellar precursors (GCPs).
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Btg1 limits the proliferation of GCPs by selectively inhibiting cyclin D1.
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Proliferation and migration of GCPs are separately controlled by Btg1 and Tis21.
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Cerebellar volume and motor coordination are altered maximally in Btg1:Tis21 KO mice.
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