Synchronous occurrence of squamous-cell carcinoma “transformation” and EGFR exon 20 S768I mutation as a novel mechanism of resistance in EGFR-mutated lung adenocarcinoma

详细信息    查看全文

• 作者：Lucia Longo^a ; Maria Cecilia Mengoli^b ; Federica Bertolini^c ; ^{bertolini.federica@policlinico.mo.it} ; ^{federica.bertolini@tiscali.it} ; Stefania Bettelli^b ; Samantha Manfredini^b ; Giulio Rossi^d
• 关键词：Lung cancer ; Adenocarcinoma ; Squamous cell carcinoma ; EGFR ; Mutation
• 刊名：Lung Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：24-26
• 全文大小：638 K
• 卷排序：103

文摘

The synchronous occurrence of SCC “transformation” and exon 20 S768I is described. SCC transformation and exon 20 S768I is an unreported mechanism of resistance. This situation is challenging for clinicians in the choice of a second line therapy.