Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease

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Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease

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作者：Julien Ettersperger¹ ; ² ; ¹¹ ; Nicolas Montcuquet¹ ; ² ; ¹¹ ; Georgia Malamut¹ ; ² ; ³ ; Nicolas Guegan¹ ; ² ; Silvia Lopez-Lastra⁴ ; ⁵ ; Sé ; golè ; ne Gayraud¹ ; ² ; Christian Reimann² ; ⁶ ; Elodie Vidal⁷ ; Nicolas Cagnard⁸ ; Patrick Villarese⁷ ; Isabelle Andre-Schmutz² ; ⁶ ; Rita Gomes Domingues⁹ ; Cristina Godinho-Silva⁹ ; Henrique Veiga-Fernandes⁹ ; Ludovic Lhermitte⁷ ; Vahid Asnafi⁷ ; Elizabeth Macintyre⁷ ; Christophe Cellier¹ ; ² ; ³ ; Kheira Beldjord⁷ ; ¹⁰ ; James P. Di Santo⁴ ; ⁵ ; Nadine Cerf-Bensussan¹ ; ² ; ¹² ; ^{nadine.cerf-bensussan@inserm.fr" class="auth_mail" title="E-mail the corresponding author} ; Bertrand Meresse¹ ; ² ; ^{bertrand.meresse@inserm.fr" class="auth_mail" title="E-mail the corresponding author}
刊名：Immunity
出版年：2016
出版时间：20 September 2016
年：2016
卷：45
期：3
页码：610-625
全文大小：5725 K

文摘

•: Innate lymphocytes with T cell traits develop in the gut epithelium
•: They differentiate in situ from hematopoietic precursors, independently of Id2
•: Their differentiation requires sequential activation of NOTCH and IL-15 signals
•: JAK1 or STAT3 mutations can favor their clonal expansion in celiac disease

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