Emerging concepts in T follicular helper cell responses to malaria

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• 作者：Diana S. Hansen^a ; ^b ; ^{hansen@wehi.edu.au} ; Nyamekye Obeng-Adjei^c ; Ann Ly^a ; ^b ; Lisa J. Ioannidis^a ; ^b ; Peter D. Crompton^c ; ^{pcrompton@niaid.nih.gov}
• 关键词：Malaria ; Protection ; Antibody responses ; T follicular helper cells ; B cells
• 刊名：International Journal for Parasitology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：47
• 期：2-3
• 页码：105-110
• 全文大小：523 K
• 卷排序：47

文摘

Immunity to malaria develops after many years of exposure to Plasmodium parasites. Clinical malaria infection is characterized by the secretion of inflammatory cytokines. Inflammatory cytokines induce TH1-like TFH cells with reduced helper capacity.