Syntheses and antiproliferative activities of novel phosphatidylcholines containing dehydroepiandrosterone moieties

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• 作者：Marek Kłobucki^a ; Aleksandra Grudniewska^a ; Damian A. Smuga^a ; Małgorzata Smuga^a ; Joanna Jarosz^b ; Joanna Wietrzyk^b ; Gabriela Maciejewska^c ; Czesław Wawrzeńczyk^a ; ^{czeslaw.wawrzenczyk@up.wroc.pl}
• 关键词：Phospholipids ; Dehydroepiandrosterone ; Antiproliferative activity ; Cytotoxic ; HL-60 ; B16
• 刊名：Steroids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：118
• 期：Complete
• 页码：109-118
• 全文大小：611 K
• 卷排序：118

文摘

Novel phosphocholines containing DHEA were synthesized. The antiproliferative activities of the novel phosphatidylcholines were studied. Incorporating DHEA at the sn-1 or sn-2 position reduces drug toxicity against normal cells (Balb/3T3). B16 and HL-60 cell lines were most sensitive to the tested phospholipids.