The pharmacological rationale for combining muscarinic receptor antagonists and 尾-adrenoceptor agonists in the treatment of airway and bladder disease

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The pharmacological rationale for combining muscarinic receptor antagonists and 尾-adrenoceptor agonists in the treatment of airway and bladder disease

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作者：Philippa R Dale¹ ; ⁷ ; Hana Cernecka² ; ³ ; ⁷ ; Martina Schmidt² ; ³ ; Mark R Dowling⁴ ; Steven J Charlton⁴ ; Michael P Pieper⁵ ; Martin C Michel⁵ ; ⁶ ; ^{marmiche@uni-mainz.de" class="auth_mail}
刊名：Current Opinion in Pharmacology
出版年：June 2014
年：2014
卷：16
期：Complete
页码：31-42
全文大小：780 K

文摘

•: Muscarinic receptors increase smooth muscle tone in airways and urinary bladder.
•: 尾-Adrenoceptors relax smooth muscle tone and oppose muscarinic contraction.
•: Opposition involves transmitter release, signal transduction and receptor expression.
•: This supports the combined use of muscarinic antagonists and 尾-adrenoceptor agonists.

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