Multivalent presentation of a hydrolytically stable GM₃ lactone mimetic as modulator of melanoma cells motility and adhesion

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• 作者：Barbara Richichi^a ; Giuseppina Comito^b ; Linda Cerofolini^a ; Gabriele Gabrielli^a ; Alberto Marra^c ; ^&dagger ; ; Lisa Moni^c ; Alice Pace^d ; Lucia Pasquato^d ; Paola Chiarugi^b ; ^{paola.chiarugi@unifi.it} ; Alessandro Dondoni^c ; Lucio Toma^e ; Cristina Nativi^a ; ^{cristina.nativi@unifi.it}
• 关键词：GM3 ganglioside ; Mimetic ; Tumour antigen ; Melanoma ; Adhesion
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2013
• 出版时间：15 May, 2013
• 年：2013
• 卷：21
• 期：10
• 页码：2756-2763
• 全文大小：931 K

文摘

A hydrolytically stable mimetic of the tumour antigen GM₃ lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination.