A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria

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• 作者：Kenneth Robert Pryde¹ ; ² ; ^{kp296@leicester.ac.uk} ; Jan Willem Taanman¹ ; Anthony Henry Schapira¹
• 关键词：mitophagy ; NADH ; ubiquinone oxidoreductase ; complex I ; mitochondrial proteases ; ClpP ; LON ; mitochondria ; retrograde signaling
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2522-2531
• 全文大小：3958 K
• 卷排序：17

文摘

Complex I is selectively vulnerable to proteolysis in depolarized mitochondria Complex I degradation extinguishes high ROS if mitophagy fails LON and ClpP bind and degrade complex I after mitochondrial stress induction Complex I abundance is coupled to mitochondrial homeostasis