¡°Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents¡±

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• 作者：Maite Arteche Pujana ; Leyre P¨¦rez-¨¢lvarez ; L. Carlos Cesteros Iturbe ; Issa Katime
• 关键词：Chitosan ; Nanogel ; pH-responsive
• 刊名：Polymer
• 出版年：2012
• 出版时间：6 July, 2012
• 年：2012
• 卷：53
• 期：15
• 页码：3107-3116
• 全文大小：941 K

文摘

Chitosan nanoparticles were obtained by crosslinking with two biocompatible dicarboxylic acids: polyethylene glycol dicarboxylic acid and tartaric acid. The water-in-oil (W/O) microemulsion method yielded particle sizes around 10-15?nm in the dried state (TEM) and 200-700?nm in the swollen state (QELS) from commercial chitosan. All the synthesized nanogels showed improved water solubility and most of them were stable at physiological pH. QELS studies revealed the influence of the hydrophilic character and flexibility of the crosslinker on the swelling behaviour of the nanogels. The nanoparticles showed a pH-sensitive volume transition that was consistent with the pKa of chitosan. The collected zeta potential data corroborated the electrostatic repulsion mechanism responsible for the pH-responsive behaviour.