刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:March 2017
年:2017
卷:1861
期:3
页码:603-614
全文大小:2336 K
卷排序:1861
文摘
Substrate preferences of NPP1 were analyzed by combining biochemical experiments, homology modeling and docking studies. All nucleotides are hydrolyzed to nucleoside 5’-monophosphates. The mechanism of 2’,3’’-cGAMP hydrolyis by NPP1 was elucidated. The cyclic dinucleotide 2’,3’’-cGAMP yields 5’-AMP and 5’-GMP, while 3’,3’’-bridged cyclic dinucleotides are not hydrolyzed.
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