Design, synthesis and cytotoxic activity of certain novel chalcone analogous compounds

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• 作者：S. El-Meligie^a ; Azza T. Taher^a ; ^b ; Aliaa M. Kamal^a ; ^{Aliaa.kamal@pharma.cu.edu.eg} ; ^{K_aliaa2511@hotmail.com} ; A. Youssef^c
• 关键词：Chalcone derivatives ; Replacing enone bridge ; Cytotoxic activity ; Cancer cell lines ; Normal cell lines ; Tubulin beta polymerization inhibitors
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：52-60
• 全文大小：740 K
• 卷排序：126

文摘

This work highlights the synthesis of a series of novel chalcone derivatives as anticancer agents. Screening the target compounds against the human breast tumor cell line (MCF-7) and human carcinoma (HepG2) was carried out. Percentage inhibition of tubulin beta depolymerization was measure for representative target compounds. Eleven out of nineteen target compounds showed broad spectrum antitumor activity.