Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

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Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

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作者：Megan R. Edwards¹ ; ² ; ⁶ ; Gai Liu² ; ⁶ ; Chad E. Mire³ ; Suhas Sureshchandra⁴ ; Priya Luthra¹ ; Benjamin Yen¹ ; Reed S. Shabman¹ ; ⁵ ; Daisy W. Leung² ; Ilhem Messaoudi⁴ ; Thomas W. Geisbert³ ; Gaya K. Amarasinghe² ; ^{gamarasinghe@path.wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; Christopher F. Basler¹ ; ^{chris.basler@mssm.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：filovirus ; immune evasion ; pattern associated molecular pattern (PAMP) ; RIG-I like receptor ; type I interferon ; VP35
刊名：Cell Reports
出版年：2016
出版时间：23 February 2016
年：2016
卷：14
期：7
页码：1632-1640
全文大小：1983 K

文摘

•: Ebola and Marburg viruses regulate interferon responses to different extents
•: Ebola and Marburg VP35 proteins block RIG-I signaling with different efficiencies
•: Ebola and Marburg VP35s have different binding modes and affinities for dsRNA
•: Ebola virus VP35 caps the ends of dsRNA for superior RIG-I suppressing function

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