Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis

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Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis

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作者：Varun Chandrashekaran^a ; ¹ ; Suvarthi Das^a ; ¹ ; Ratanesh Kumar Seth^a ; Diptadip Dattaroy^a ; Firas Alhasson^a ; Gregory Michelotti^c ; Mitzi Nagarkatti^b ; Prakash Nagarkatti^b ; Anna Mae Diehl^c ; Saurabh Chatterjee^a ; ^{schatt@mailbox.sc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：CYP2E1 ; cytochrome P450 ; family 2 ; subfamily E ; polypeptide 1 ; NASH ; nonalcoholic steatohepatotitis ; P2X7r ; purinergic receptor X7 ; GLUT4 ; glucose transporter 4 ; IL-1β ; interleukin 1β ; BDCM ; bromodichloromethane ; NAFLD ; nonalcoholic fatty liver disease ; CCl4 ; carbon tetrachloride ; DAS ; diallyl sulfide ; α-SMA ; alpha smooth muscle actin ; PI3K ; phosphatidylinositol-4 ; 5-bisphosphate 3-kinase ; AKT ; protein kinase B ; ATP ; adenosine tri-phosphate ; BzATP ; Benzoyl O ATP ; HK ; hexokinase
刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年：2016
出版时间：January 2016
年：2016
卷：1862
期：1
页码：32-45
全文大小：3271 K

文摘

•: Leptin is required for P2X7r induction in NASH progression.
•: Leptin-mediated P2X7r induction determine hepatic stellate cell activation in vivo and in vitro.
•: Leptin-mediated P2X7r induction of Glut4 in hepatic stellate cells requires PI3/AKT pathway.
•: P2X7r induced higher Glut4 protein leads to increased intracellular glucose and hexokinase activity in hepatic stellate cells.
•: P2X7r is downstream of leptin-mediated hepatic stellate cell activation in NASH progression.

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