The potential role of Piezo2 in the mediation of visceral sensation

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The potential role of Piezo2 in the mediation of visceral sensation

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作者：Jing Yang ; Jianna Zhang ; Hongli Yang ; Kun Li ; Xiaofei Lei ; Changqing Xu ; ^{xcqys@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：shRNA ; short hairpin RNA ; DRG ; dorsal root ganglia ; TL ; thoracolumbar ; LS ; lumbosacral ; AWR ; abdominal withdrawal reflex ; EMG ; electromyography ; CRD ; colorectal distension
刊名：Neuroscience Letters
出版年：2016
出版时间：6 September 2016
年：2016
卷：630
期：Complete
页码：158-163
全文大小：1294 K

文摘

•: Intrathecal Piezo2-short hairpin RNA (shRNA) reduced Piezo2 expression in lumbosacral dorsal root ganglia.
•: Intrathecal Piezo2-shRNA attenuated visceral sensation to innocuous stimuli under physiological conditions.
•: Intrathecal Piezo2-shRNA attenuated visceral sensation to both innocuous and noxious stimuli under hyperalgesic conditions.

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