Autoimmune Cardiotoxicity of Cancer Immunotherapy

详细信息    查看全文

• 作者：Feixiong Cheng¹ ; ² ; ^{fxcheng1985@gmail.com} ; Joseph Loscalzo³ ; ^{jloscalzo@partners.org}
• 关键词：cardio-oncology ; ipilimumab ; nivolumab ; immune checkpoint ; immunotherapy.
• 刊名：Trends in Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：2
• 页码：77-78
• 全文大小：399 K
• 卷排序：38

文摘

Contemporary immunotherapies (e.g., immune checkpoint inhibitors), which enhance the immune response to cancer cells, improve clinical outcomes in several malignancies. A recent study reported the cases of two patients with metastatic melanoma who developed fatal myocarditis during ipilimumab and nivolumab combination immunotherapy; these examples highlight the risk of unbridled activation of the immune system.