Genetic variants in microRNA-146a (C </ce:hsp>> </ce:hsp>G) and microRNA-1269b (G </ce:hsp>> </ce:hsp>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer

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Genetic variants in microRNA-146a (C > G) and microRNA-1269b (G > C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer

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作者：Hung-Chih Chen^a ; ^b ; ¹ ; Yu-Kai Tseng^c ; ^d ; ² ; Chao-Chuan Chi^e ; ³ ; Yu-Hung Chen^a ; ⁴ ; Cheng-Mei Yang^a ; ^b ; ⁵ ; Sin-Jhih Huang^f ; ⁶ ; Yi-Cheng Lee^f ; ^g ; ⁷ ; Huei-Han Liou^f ; ⁸ ; Kuo-Wang Tsai^f ; ^h ; ⁹ ; ^{kwtsai@vghks.gov.tw" class="auth_mail" title="E-mail the corresponding author} ; Luo-Ping Ger^f ; ⁱ ; ¹⁰ ; ^{lpger@vghks.gov.tw" class="auth_mail" title="E-mail the corresponding author}
关键词：Oral cancer ; Pharyngeal cancer ; Polymorphisms ; miR-146a ; miR-1269b ; Risk
刊名：Archives of Oral Biology
出版年：2016
出版时间：December 2016
年：2016
卷：72
期：Complete
页码：21-32
全文大小：562 K

文摘

•: To the best of our knowledge, miR-1269b polymorphism has never been investigated in any premalignant lesions or cancers.
•: This is the first study to find that the genetic variants of miR-1269b are associated with a decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer.