Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract

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• 作者：Fedor V. Vityazev^a ; ^{rodefex@mail.ru} ; Maiia I. Fedyuneva^a ; Victoria V. Golovchenko^a ; Olga A. Patova^a ; Elena U. Ipatova^b ; Eugene A. Durnev^c ; Ekaterina A. Martinson^c ; Sergey G. Litvinets^c
• 关键词：Tetraethoxysilane (PubChem CID ; 6517) ; Ethanol (PubChem CID ; 702) ; Hydrochloric acid (PubChem CID ; 313) ; Sodium metasilicate (PubChem CID ; 23266) ; Sodium chloride (PubChem CID ; 5234) ; Potassium dihydrogen phosphate (PubChem CID ; 516951) ; Calcium chloride (PubChem CID ; 5284359) ; 5-Aminosalicylic acid (PubChem CID ; 4075)
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：9-20
• 全文大小：2894 K
• 卷排序：157

文摘

The synthesis of pectin-silica gels using low and high methoxyl pectins and TEOS is described. The gelation depends on degree of methylation of pectin and TEOS concentration. The IR spectra of the pectin-silica gels indicate the formation of hydrogen and covalent bonds between silica and pectin macromolecules. Different pectin-silica beads with mesalazine were synthesized by combination of sol-gel and ionotropic gelation methods. The drug release of pectin-silica beads in simulated GIT occurs gradually and is dependent on the beads hardness.