Clinical characteristics and outcomes of septic patients with new-onset atrial fibrillation

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• 作者：Sangita-Ann Christian ; Christa Schorr ; Lynn Ferchau ; Maria E. Jarbrink ; Joseph E. Parrillo ; David R. Gerber
• 关键词：Sepsis ; Atrial fibrillation ; ICU
• 刊名：Journal of Critical Care
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：23
• 期：4
• 页码：532-536
• 全文大小：222 K

文摘

Purpose

No studies have specifically evaluated the incidence or clinical characteristics of atrial fibrillation (AF) in a mixed medical-surgical population of patients with sepsis. We undertook to determine the incidence and clinical course of critically ill septic patients in the intensive care unit (ICU) who developed new-onset AF.

Methods

Retrospective analysis of data collected from the Project IMPACT database on 274 septic patients from July 2003 to December 2004.

Results

Sixteen evaluable septic patients with new-onset AF were identified. Mortality was higher (P = .034) and ICU length of stay (LOS) longer (P = .003) in patients with AF vs those without. Intensive care unit LOS was also longer in the subset of survivors with AF (P = .0001). Hospital LOS was longer among survivors with AF than in survivors without AF (P = .047). Patients with AF had a greater need for mechanical ventilation (P = .0007). Survivors with AF had longer duration of mechanical ventilation than those without AF (P = .006).

Conclusions

Statistically significantly higher mortality was observed in critically ill septic patients with new-onset AF, as were longer duration of mechanical ventilation, ICU, and hospital LOS. Whether the higher incidence of AF in septic patients is a specific risk factor for outcome or an indication of severity of illness remains to be determined.