Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia

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Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia

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作者：Michaela Schä ; fer¹ ; ² ; ⁴ ; ¹³ ; Christian U. Oeing³ ; ⁴ ; ¹⁴ ; Maria Rohm¹ ; ² ; ¹³ ; Ezgi Baysal-Temel³ ; ⁴ ; ¹⁴ ; Lorenz H. Lehmann³ ; ⁴ ; ¹⁴ ; Ralf Bauer³ ; ⁴ ; H. Christian Volz⁷ ; ⁴ ; Michael Boutros⁷ ; ⁴ ; Daniela Sohn¹ ; ² ; ¹³ ; Carsten Sticht⁵ ; Norbert Gretz⁵ ; Katrin Eichelbaum¹² ; Tessa Werner¹⁰ ; ¹¹ ; Marc N. Hirt¹⁰ ; ¹¹ ; Thomas Eschenhagen¹⁰ ; ¹¹ ; Karin Mü ; ller-Decker⁸ ; Oliver Strobel⁹ ; Thilo Hackert⁹ ; Jeroen Krijgsveld⁶ ; Hugo A. Katus³ ; ⁴ ; Mauricio Berriel Diaz¹ ; ² ; ¹³ ; Johannes Backs³ ; ⁴ ; ¹⁴ ; ^{johannes.backs@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Stephan Herzig¹ ; ² ; ⁴ ; ¹³ ; ^{stephan.herzig@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Cancer cachexia ; Ataxin-10 ; Cardiac dysfunction ; Fatty acid metabolism
刊名：Molecular Metabolism
出版年：2016
出版时间：February 2016
年：2016
卷：5
期：2
页码：67-78
全文大小：2429 K

文摘

•: Cancer cachexia induces remodeling of the heart.
•: Tumor-borne secreted factors mediate cardiomyocyte atrophy.
•: Selective cachexokines, including Bin1, Stx7, Minpp1, Gaa, Ccl2, Adamtsl4, and Atxn10 provoke aberrant cardiac FA metabolism.
•: Ataxin-10 levels are elevated under cachectic conditions in mice and tumor patients.

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