Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults

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• 作者：David P. Sheppard ; MAAuthor Vitae ; Erica Weber ; PhDAuthor Vitae ; Kaitlin B. Casaletto ; MSAuthor Vitae ; Gunes Avci ; PhDAuthor Vitae ; Steven Paul Woods ; PsyD ; ^{spwoods@uh.edu" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; The HIV Neurobehavioral Research Program (HNRP) GroupIgor Grant ; MD ; J. Hampton Atkinson ; MD ; Ronald J. Ellis ; MD ; PhD ; J. Allen McCutchan ; MD ; Thomas D. Marcotte ; PhD ; Jennifer Marquie-Beck ; MPH ; Melanie Sherman ; Ronald J. Ellis ; MD ; PhD (Principal Investigator) ; J. Allen McCutchan ; MD ; Scott Letendre ; MD ; Edmund Capparelli ; PharmD ; Rachel Schrier ; PhD ; Debra Rosario ; MPH ; Robert K. Heaton ; PhD (Principal Investigator) ; Mariana Cherner ; PhD ; Jennifer E. Iudicello ; PhD ; David J. Moore ; PhD ; Erin E. Morgan ; PhD ; Matthew Dawson ; Terry Jernigan ; PhD (Principal Investigator) ; Christine Fennema-Notestine ; PhD ; Sarah L. Archibald ; MA ; John Hesselink ; MD ; Jacopo Annese ; PhD ; Michael J. Taylor ; PhD ; Eliezer Masliah ; MD (Principal Investigator) ; Cristian Achim ; MD ; PhD ; Ian Everall ; FRCPsych ; FRCPath ; PhD (Consultant) ; Douglas Richman ; MD (Principal Investigator) ; David M. Smith ; MD ; J. Allen McCutchan ; MD (Principal Investigator) ; Cristian Achim ; MD ; PhD (Principal Investigator) ; Stuart Lipton ; MD ; PhD ; J. Hampton Atkinson ; MD (Principal Investigator) ; Anthony C. Gamst ; PhD (Principal Investigator) ; Clint Cushman (Data Systems Manager) ; Ian Abramson ; PhD (Principal Investigator) ; Florin Vaida ; PhD ; Reena Deutsch ; PhD ; Anya Umlauf ; MS
• 关键词：adherence ; aging ; HIV ; pill burden ; prospective memory
• 刊名：Journal of the Association of Nurses in AIDS Care
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：27
• 期：5
• 页码：595-607
• 全文大小：312 K

文摘

Prospective memory (PM) is associated with antiretroviral (ARV) adherence in HIV, but little is known about how pill burden and age might affect this association. One hundred seventeen older (≥50 years) and 82 younger (<50 years) HIV-infected adults were administered a measure of PM in the laboratory and subsequently were monitored for ARV adherence for 30 days using the Medication Event Monitoring System. In the older group, better time-based PM performance was associated with higher likelihood of adherence, irrespective of pill burden. Within the younger sample, time-based PM was positively related to adherence only in participants with lower pill burdens. Younger HIV-infected individuals with higher pill burdens may overcome the normal effects of time-based PM on adherence through compensatory medication-taking strategies, whereas suboptimal use of these strategies by younger HIV-infected individuals with lower pill burdens may heighten their risk of ARV nonadherence secondary to deficits in time-based PM.