Adaptive reorganization of retinogeniculate axon terminals in dorsal lateral geniculate nucleus following experimental mild traumatic brain injury

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• 作者：Vishal C. Patel ^{vpatel4@vcu.edu} ; Christopher W.D. Jurgens ^{cjurgens@vcu.edu} ; Thomas E. Krahe ^{tekrahe@gmail.com} ; John T. Povlishock ; ^{john.povlishock@vcuhealth.org}
• 关键词：AP ; anterior posterior ; cFPI ; central fluid percussion injury ; CTB ; cholera toxin β ; DAI ; diffuse axonal injury ; dLGN ; dorsal lateral geniculate nucleus ; mTBI ; mild traumatic brain injury ; VGLUT2 ; vesicular glutamate transporter 2
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：289
• 期：Complete
• 页码：85-95
• 全文大小：1425 K
• 卷排序：289

文摘

We confirm that mild traumatic brain injury induces deafferentation in the LGN. Diffuse deafferentation in LGN triggers adaptive reorganization among intact axons. This reorganization maintains eye specific segregation of axon terminals. Different retinal ganglion cell subpopulations may vary their response to injury.