Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile<sup>9</sup>]PK20 in an acute pain treatment in rodents

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Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile⁹]PK20 in an acute pain treatment in rodents

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作者：Patrycja Kleczkowska^a ; ^b ; ^{hazufiel@wp.pl" class="auth_mail" title="E-mail the corresponding author} ; Emmanuel Hermans^c ; Piotr Kosson^b ; Agnieszka Kowalczyk^a ; Anna Lesniak^b ; Karolina Pawlik^a ; Engin Bojnik^d ; Sandor Benyhe^d ; Barbara Nowicka^b ; Magdalena Bujalska-Zadrozny^a ; Aleksandra Misicka^b ; Andrzej W. Lipkowski^b
关键词：CHO ; Chinese hamster ovary (cells) ; Dmt ; 2&rsquo ; 6&rsquo ; -dimethyl-(S)-tyrosine ; EC50 ; half maximal effective concentration ; [35S]-GTPγS ; guanosine-5-[γ-35S]-triphosphate ; HOBt ; 1-hydroxybenzotriazole ; RP-HPLC ; reverse phase-high preparative liquid chromatography ; i.c.v. ; intracerebrovetricular ; i.p. ; intraperitoneal ; i.t. ; intrathecal ; i.v. ; intravenous ; Ki ; inhibition constant ; MPE ; maximal possible effect ; NTS1 ; neurotensin 1 receptor ; PEI ; polyethyleneimine ; TBTU ; O-(Benzotriazol-1-yl)-N ; N
刊名：Brain Research
出版年：2016
出版时间：1 October 2016
年：2016
卷：1648
期：part_PA
页码：172-180
全文大小：1024 K

文摘

•: Activity of the drugs are related to the form of their administration.
•: Compounds exerted spinal dose- and time-dependent analgesia.
•: The mixture of both pharmacophores occurred to be more active than the chimera.
•: Motor impairments surfaced as a side effect after application of the mixture.