Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3

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Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3

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作者：Jian Fu ; ^{jian_fu@urmc.rochester.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：cIAP ; cellular inhibitor of apoptosis protein ; DFX ; Desferrioxamine ; DMOG ; dimethyl oxalylglycine ; EGLN ; Caenorhabditis elegans gene egl-9 ; HA ; hemagglutinin ; HEK293 cells ; human embryonic kidney 293 cells ; IB ; immunoblotting ; IP ; immunoprecipitation ; HIF ; hypoxia-inducible factor ; IKK ; IκB kinase ; K ; lysine ; R ; arginine ; RIP1 ; receptor-interacting protein 1 ; siRNA ; small interfering RNA ; SM ; Smac mimetic ; TAB ; TAK1-binding protein ; TAK1 ; transforming growth factor β-activated kinase 1 ; TNF ; tum
刊名：Cellular Signalling
出版年：2016
出版时间：February 2016
年：2016
卷：28
期：2
页码：72-80
全文大小：1333 K

文摘

•: EGLN3 interacts with both the E3 ubiquitin ligase cIAP1 and RIP1.
•: EGLN3 interferes with the association between RIP1 and cIAP1.
•: EGLN3 inhibits K63-linked polyubiquitination of RIP1.
•: The ubiquitination-inhibiting effect of EGLN3 is independent of its hydroxylase activity.
•: EGLN3 attenuates RIP1-induced NFκB activation.

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