Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo

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Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo

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作者：Toros A. Dincman^a ; Jason E. Beare^b ; ^d ; Sujata Saraswat Ohri^b ; ^e ; Vittorio Gallo^g ; Michal Hetman^b ; ^e ; ^f ; Scott R. Whittemore^b ; ^c ; ^e ; ^{swhittemore@louisville.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：BBB ; blood-brain barrier ; BSA ; bovine serum albumin ; CC3 ; cleaved caspase 3 ; CICI ; chemotherapy-induced cognitive impairment ; CNPase ; 2&prime ; 3&prime ; -cyclic-nucleotide phosphodiesterase ; CNS ; central nervous system ; DMSO ; dimethyl sulfoxide ; EGFP ; enhanced green fluorescent protein ; FGF-2 ; fibroblast growth factor-2 ; GAPDH ; glyceraldehydes 3-phosphate dehydrogenase ; HAT ; histone acetyltransferase ; HDA ; Chistone deacetylase ; HDA ; Cihistone deacetylase inhibitor ; NDS ; normal donkey serum ; OL ; oli
刊名：International Journal of Developmental Neuroscience
出版年：2016
出版时间：November 2016
年：2016
卷：54
期：Complete
页码：53-61
全文大小：2260 K

文摘

•: HDAC mRNA expression patterns differ between OPCs and mature OLs/astrocytes.
•: HDAC inhibition negatively affects viability of OPCs, OLs, and astrocytes.
•: HDAC inhibitor-mediated cytotoxicity preferentially affects OPCs.
•: The cytotoxicity is partially mediated by Cleaved Caspase 3 both in vitro & in vivo.
•: SAHA is an FDA approved drug and may be harmful to patients.

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