Oxytocin, a main breastfeeding hormone, prevents hypertension acquired in utero: A therapeutics preview

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• 作者：Froylá ; n Vargas-Martí ; nez^a ; ^{fmvargas@fisio.cinvestav.mx} ; Richard J. Schanler^b ; Steven A. Abrams^c ; Keli M. Hawthorne^c ; Susan Landers^d ; José ; Guzman-Bá ; rcenas^e ; Onofre Muñ ; oz^e ; Tore Henriksen^f ; Maria Petersson^g ; Kerstin Uvnä ; s-Moberg^h ; Ismael Jimé ; nez-Estrada^a
• 关键词：IUGR ; DNA methylation ; oxytocin ; neuroprotection ; development ; hypertension
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3071-3084
• 全文大小：1048 K
• 卷排序：1861

文摘

Our review article is presenting advanced information: The main epigenetics anomalies that produce this Prenatal Programming of Hypertension (Table 1); Plausible explanations how this is occurring in utero (Fig. 1); Biochemical homeostasis unbalance due to key deficient nuclear hormone receptors (Table 1, and Section 5), regulators of ROS balance, circadian rhythms, and homeostasis of metabolic pathways (oxytocin, ANF, etc. Fig. 2), that imposes high blood pressure; We discuss why and how Oxytocin-Receptor Signaling can overcome this biochemical homeostasis unbalance, early postnatal (Section 6, Fig. 3).