Platinum based radiochemotherapies: Free radical mechanisms and radiotherapy sensitizers

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Platinum based radiochemotherapies: Free radical mechanisms and radiotherapy sensitizers

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作者：Clifford W. Fong ^{cwfong@internode.on.net" class="auth_mail" title="E-mail the corresponding author}
关键词：AEA ; adiabatic electron affinity ; 5FU ; 5-fluorocil ; G ; Guanine ; HOMO ; highest occupied molecular orbital ; LUMO ; lowest unoccupied molecular orbital ; ET ; electron transfer ; DET ; dissociative electron transfer ; PCET ; proton coupled electron transfer ; NAPCET ; nucleophilic assisted proton coupled electron transfer ; TS ; transition state ; ΔG&Dagger ; free energy of activation ; ΔH&Dagger ; enthalpy of activation ; ΔS&Dagger ; entropy of activation ; FOLFOX ; oxaliplatin+5-fluorocil+folinic acid combinatio
刊名：Free Radical Biology and Medicine
出版年：2016
出版时间：October 2016
年：2016
卷：99
期：Complete
页码：99-109
全文大小：599 K

文摘

•: Free radical mechanisms of Pt radiosensitizers.
•: Oxaliplatin has a different radiosensitizing mechanism than cisplatin, carboplatin, or nedaplatin.
•: Oxaliplatin π complexes with 5-FU in FOLFOX more potently under acidic conditions.
•: Pt drug administration can be optimized by understanding the mechanisms of radiosensitization.

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