Efficient synthesis of 2,3-unsaturated sulfonamidoglycosides by Amberlyst 15

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• 作者：Carlos A. Té ; mpera ; Pedro A. Colinas ; Rodolfo D. Bravo
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：13 October 2010
• 年：2010
• 卷：51
• 期：41
• 页码：5372-5374
• 全文大小：247 K

文摘

Sulfonamidoglycosylation of d-glycals in the presence of Amberlyst 15 proceeded effectively to afford the sulfonamidoglycosides in good to high yields with minimal workup and short reaction times. Two N-glycosyl sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.